Background & Aim: Multiple sclerosis, like all other chronic diseases, affects the health and quality of life of people with undesirable effects. The purpose of this study is investigate the relationship between perceived social support and spiritual intelligence by improving the quality of life of patients with multiple sclerosis. 

Materials and Methods: Correlation study and statistical population of this study included all patients with multiple myeloma sclerosis.this research was conducted in Tehran in September, 2016, among which 100 were selected by simple random sampling method. Data were collected by World Health Organization Quality of Life Questionnaire, Perceived Support Multifaceted Scale and Spiritual Intelligence Questionnaire. Data were analyzed using Pearson correlation and hierarchical regression analysis.

Results: There was a significant positive correlation between perceived social support and spiritual intelligence with quality of life. Perceived social support or standard tilt coefficient is equal to (β = 0.382) that affects the quality of life of patients, and the main members of the family are more effective in protecting patients. Spiritual intelligence of the standard tilt coefficient was equal to (β = 0.499) which positively and significantly influenced the quality of life, Therefore, quality of life is based on perceived social support and spiritual wisdom of patients with multiple sclerosis.

 Conclusion: Social support is a two-way interaction. Social support perceived by the family and important people of life positively predict physical health, mental health, social relationships, which have contributed to improving the quality of life of patients and reducing the incidence of multiple sclerosis. Also, the existence of strong spiritual intelligence in people with multiple sclerosis has an important role in adapting and solving problems affecting the quality of life of patients. And on this basis, the forerunner is social protection and spirituality, which affects the quality of life of patients.