Background and Aim:. Regional territory of the health care system in the field of the country provides the opportunity to the participation in the programs of the Ministry of Health based on the advantages and talents of the region and enables the programs to be improved further. The purpose of this study is to explain the reform of territorial planning, transformation and innovation in higher level of education in Iran.

Materials and Methods: Using keywords from the articles’ title or abstract in books prepared by the Educational Deputy of the Health Ministry and from the databases like Magiran, SID, Iranmedex, Google Scholar for studies in Persian from 1380 to 1395. English articles with Keywords” Territorial planning, Transformation in medical science education, Innovation in medical science education” were searched in PubMed, Science direct, Google Scholar between 2000 and 2016.

Results: This search initially found 1790 articles, in which there were only 22 articles, and 7 books having inclusion criteria. Nine of them were English and the rest were Persian.The results showed that universities from every metropolitan area interacting with each other, conducted Health Ministry policies.The Comprehensive Education Program contained 12 general policies and orientations. In order to conduct it, 11 packages for developing and innovating in medical education along with a monitoring program were developed. In other countries with the implementation of a targeted inter-university interaction program, transformation and innovation arose in the environment of  academic places.

Conclusion: Regional territory reform leads to Transformation and innovation in medical education and also providing resources, expanding educational opportunities and attracting faculty members’ contribution will make the program be successful.